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Raphaël Ognar

Raphaël Ognar

President, CEO, Co-Founder & Chairman, NKILT Therapeutics

Raphaël Ognar is President, CEO, Co-Founder and Chairman of NKILT Therapeutics, a biotech developing an allogeneic cell therapy technology. He spent years inside big pharma running drug development programs and working on P&L in strategy for the CEO and CFO, carrying two small molecules through to approval.

He left that track, along with the salary and the career path attached to it, to build a consultancy and then to found his own company. He is direct about what the transition cost him personally and professionally. On Open Door Salon he describes finding a scientific citation an AI had invented, and makes the case that the human review layer in drug development cannot be delegated to a model.

Frequently Asked Questions About Raphaël Ognar

Who is Raphaël Ognar?

Raphaël Ognar is President, CEO, Co-Founder and Chairman of NKILT Therapeutics, a biotech developing an allogeneic cell therapy technology. He spent years inside big pharma running drug development programs and working on P&L in strategy for the CEO and CFO, and he carried two small molecules through to approval. He left that track to build a consultancy and then to found his own company.

What does Raphaël Ognar say about failure at big pharma versus a small biotech?

Raphaël Ognar leads NKILT Therapeutics, a small biotech developing an allogeneic cell therapy technology, after years inside big pharma. On Open Door Salon, discussing who can absorb a delay, he tied how a company treats failure to its cash position: “big pharma doesn’t characterize failure the same way a small biotech will just for a very simple reason. Big pharma has cash and we don’t as small biotechs”.

What does Raphaël Ognar argue about AI in drug development?

Raphaël Ognar argues that the human review layer in drug development cannot be delegated to a model. On Open Door Salon he described finding a scientific citation an AI had invented, and quoted what he told it: “I said I don’t know is more than satisfactory and it’s definitely better than lying”. He treats prompting as a discipline of its own: “if you don’t ask the right question, you cannot expect the right answer”. He has also said his own pitch deck contains no mention of AI.

What did Raphaël Ognar leave behind to found NKILT Therapeutics?

Raphaël Ognar left big pharma, along with the salary and the career path attached to it, to build a consultancy and then to found his own company, NKILT Therapeutics. He is direct about what the transition cost him personally and professionally.

On Open Door Salon

“Ryan Cawood and Raphaël Ognar on What Happens When AI Gets Drug Discovery Wrong”
Ryan Cawood & Raphaël Ognar · August 26, 2026

Episode page & show notes on Open Door Salon

“I said I don’t know is more than satisfactory and it’s definitely better than lying”Raphaël Ognar, on Open Door Salon (on what he told the AI that invented a citation)
“if you don’t ask the right question, you cannot expect the right answer”Raphaël Ognar, on Open Door Salon (on prompting as a discipline)
“big pharma doesn’t characterize failure the same way a small biotech will just for a very simple reason. Big pharma has cash and we don’t as small biotechs”Raphaël Ognar, on Open Door Salon (on who can absorb a delay)
“my pitch deck for example doesn’t have one mention of AI and everybody’s telling me you need to put AI in your pitch deck”Raphaël Ognar, on Open Door Salon (on refusing to advertise AI)

In this episode

  • The publication that did not exist
  • The AI admitted it invented the publication
  • The DNA sequence it read confidently and wrong
  • Who is liable when the model is wrong
  • What a mistake actually looks like in a lab
  • Build checkpoints into the prompt, not just at the end
  • Failure at big pharma versus failure at a small biotech
  • Trials are designed for approval, not for the real world
  • Nine months of chain of custody, recorded on paper
  • Greed versus outcome in the AI bubble
  • The pitch deck with no mention of AI

Topics

AI in Drug DiscoveryAllogeneic Cell TherapyDrug DevelopmentBig Pharma vs Small BiotechClinical Trial Design

Watch on Open Door Salon

What Happens When AI Gets Drug Discovery Wrong | Ryan Cawood & Raphaël Ognar

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